Principal Software Engineer

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Principal Software Engineer in USA new

Natera
Full time
Email

USA
10/13/2026
Report

South San Francisco, CA

Responsibilities

Own the architecture, implementation, and delivery of major initiatives across cloud infrastructure, workflow platforms, and data platforms.
Lead architecture and design reviews and influence technical decisions across the engineering team.
Mentor mid-level engineers through code reviews, design documents, and pairing.
Build and improve AI-coding tooling, including agent-driven software development tools.
Partner with the team lead on roadmap, prioritization, and complex technical decisions.
Collaborate with bioinformaticians, scientists, and R&D engineers to translate needs into platform capabilities.
Ship production software for internal or external end users and own multi-quarter technical initiatives.

Requirements

10+ years of professional software engineering experience across a range of systems and problem types.
Production experience designing for a major cloud platform, with AWS preferred or GCP/Azure equivalent.
Production experience with Kubernetes or an equivalent container orchestration platform, including cluster design, scheduling, networking, and workload patterns.
Production experience with Terraform or an equivalent infrastructure-as-code tool, including shared modules and multi-environment deployments.
Strong proficiency in at least one general-purpose programming language such as Python, Go, or Java.
Experience shipping end-user software and understanding product requirements, user feedback, and competing priorities.
Previous engineering team leadership and mentorship of junior engineers.
Experience working in fast-moving, startup-like environments and delivering quickly.
Familiarity with AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, and React.
Interest in AI-native development and building tooling that improves engineering productivity.
Preferred experience includes scientific or bioinformatics computing, LIMS or laboratory data systems, workflow orchestration, ETL or data pipelines, and HPC or batch-compute platforms.

Benefits

Competitive base salary and benefits.
Annual performance incentive bonus and long-term equity awards.
Comprehensive medical, dental, vision, life, and disability benefits.
401(k) with company match, paid time off, company holidays, commuter benefits, wellness and work-life benefits, and referral program.
Eligible employees and immediate family members receive free testing and fertility care benefits.
South San Francisco, California is preferred; remote work is optional.
Full-time position.

Salary: $220k - $275k/yr

Natera

Natera™ is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to...

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